发明名称 |
MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY |
摘要 |
Compositions containing a carrier and microbubbles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 mL oxygen/dL suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs. |
申请公布号 |
US2012156300(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
US201213402409 |
申请日期 |
2012.02.22 |
申请人 |
KHEIR JOHN;BORDEN MARK ANDREW;MCGOWAN FRANCIS X.;THE TRUSTEES OF COLUMBIA UNIVERSITY;THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
KHEIR JOHN;BORDEN MARK ANDREW;MCGOWAN FRANCIS X. |
分类号 |
A61K9/14;A61K33/00;A61P7/00;A61P9/00;A61P9/10 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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