发明名称 HUMANIZED ANTI-IL-10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).
摘要 <p>Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.</p>
申请公布号 MX2012006198(A) 申请公布日期 2012.06.19
申请号 MX20120006198 申请日期 2010.11.30
申请人 BIOTEST AG 发明人 CHRISTOPH BRUECHER;BENJAMIN DAELKEN;FRANK OSTERROTH;CHRISTOPH UHEREK;CHANTAL ZUBER;NIKLAS CZELOTH;ANDRE ENGLING;PETER ROETTGEN
分类号 A61K39/395;C07K16/24 主分类号 A61K39/395
代理机构 代理人
主权项
地址