发明名称 |
HUMANIZED ANTI-IL-10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). |
摘要 |
<p>Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL- 10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.</p> |
申请公布号 |
MX2012006198(A) |
申请公布日期 |
2012.06.19 |
申请号 |
MX20120006198 |
申请日期 |
2010.11.30 |
申请人 |
BIOTEST AG |
发明人 |
CHRISTOPH BRUECHER;BENJAMIN DAELKEN;FRANK OSTERROTH;CHRISTOPH UHEREK;CHANTAL ZUBER;NIKLAS CZELOTH;ANDRE ENGLING;PETER ROETTGEN |
分类号 |
A61K39/395;C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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