发明名称 LOX-1 ANTAGONIST AGENT
摘要 <P>PROBLEM TO BE SOLVED: To provide a high safety antagonist agent for an oxidized LDL receptor LOX-1 which is expressed by a vascular endothelial cell, macrophage or the like, and to provide a food composition, and a prophylactic agent and a therapeutic agent of a cardiovascular disease or cancer containing the same. <P>SOLUTION: The antagonist agent comprises flavonoid gallate shown by the following formula (1) as an active ingredient. In the formula, R1-R4 are H or -CH3, R5-R8 are H, -OH or -OCH3, R1-R4 each may be the same group or the different group, and R5-R8 each may be the same group or different group. <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012111747(A) 申请公布日期 2012.06.14
申请号 JP20110236448 申请日期 2011.10.27
申请人 UHA MIKAKUTO CO LTD;NATIONAL CEREBRAL & CARDIOVASCULAR CENTER 发明人 SHINKE YASUHIRO;DOI SATOSHI;KUZUMI AKINOBU;MATSUKAWA TAIJI;MATSUI TAKEKI;YAMADA YASUMASA;YAMADA ICHIRO;SAWAMURA TATSUYA
分类号 A61K31/353;A61P9/00;A61P9/10;A61P35/00;A61P43/00;C07D311/62 主分类号 A61K31/353
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