USE OF PHENETHYL CAFFEATE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT AGAINST TUMOR ANGIOGENESIS

摘要

Disclosed is the use of the compounds represented by formula (I) in the preparation of a medicament against tumor angiogenesis, wherein R1 and R2 respectively independently represent a C1-C8 alkylidene group, a C2-C8 alkenylidene group; A1 and A2 respectively independently represent an aryl group, an isoaryl group or an aryl or isoaryl group optionally substituted by halo, -CN, -NO2, -OH, -SH, -OR3, -SR3, -R3, -R3-OR4, -C(O)R3, -S(O)R3, -S(O)2R3, -NR4R5, -C(O)OR3, -C(O)NR4R5, -O(O)CR4, -S(O)CR4 or -NR4(O)CR5 substituents, wherein R3 represents a C1-C4 alkyl group, R4 and R5 respectively independently represent hydrogen, a C1-C4 alkyl or aryl or substituted aryl group; and X and Y respectively independently represent oxygen; and the compounds represented by formula (I) do not include phenethyl caffeate.