GB1 PEPTIDIC LIBRARIES AND COMPOUNDS, AND METHODS OF SCREENING THE SAME

摘要

GB 1 peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Aspects of the methods include screening GB 1 peptidic libraries for specific binding to 40 residue or more D-target proteins. Once a L-peptidic compound has been identified that specifically binds to the D-target protein, the D-enantiomer of that compound may be produced. GB 1 peptidic compounds that specifically bind to a target molecule are also provided. These libraries, compounds and methods find use in a variety of applications in which specific binding to target molecules, e.g., target proteins is desired.