| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperone (ASSC) to increase stability and efficiency of the protein being administered, compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions. <P>SOLUTION: In the method, the purified protein is enzyme, and the active-specific chaperone is the reversible competitive inhibitor of the enzyme. Further, the reversible competitive inhibitor is a compound selected from a group consisting of 1-deoxygalactonojirimycin, α-arrow homonojirimycin, α-galacto-homonojirimycin, α-1-C-buthyl-deoxynojirimycin, calystegine A3, calystegine B2, N-methyl-calystegine A3 and N-methyl-calystegine B2. <P>COPYRIGHT: (C)2012,JPO&INPIT |
