MODIFIED ANTICOMPLEMENTARY OLIGONUCLEOTIDES WITH ANTICANCER PROPERTIES AND METHOD FOR PRODUCING SAME

摘要

The invention can be used in medicine and veterinary science to create a drug that is effective in the treatment of cancerous diseases in humans and animals. The modified anticomplementary oligonucleotides with anticancer properties and the method for producing same are characterized in that a mixture of polynucleotide hydrolysis products is used as oligonucleotides, and modification is carried out by changing the charges of the molecules of the nucleotide bases to an opposite charge so that said bases acquire anticomplementary properties. The polynucleotides are hydrolyzed using natural and synthetic nucleases and acid or alkaline hydrolysis, and the structure is modified by acylation of the aminogroups of the mononucleotides in the oligonucleotide structure using dicarboxylic acid anhydrides or by alkylation using halogen carboxylic acids. The claimed mixture has the ability to bind selectively to mRNA and thus stop the synthesis of protein in cancer cells, similar to the action of microRNA. Since the drug is able to adapt to an organism, it can be used without risk of a tumour becoming habituated to the drug. The agent has a broad spectrum of action, low toxicity and is suitable for industrial production as well as being effective at all stages in the cancer process.