| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide proteins having N-glycosylated optimized proteins, produced in prokaryotes; to provide a method for producing the protein; to provide methods of introducing to recombinant protein N-glycans for the improvement of antigenic, stability and biological activity of the proteins; and to provide host cells displaying the recombinant N-glycosylated proteins on their surface. <P>SOLUTION: There are provided: recombinant N-glycosylated protein containing one or more introduced N-glycosylated optimized amino acid sequence(s); nucleic acids encoding these proteins as well as corresponding vectors; and host cells. In addition, the present invention is directed to the use of the proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing the proteins. <P>COPYRIGHT: (C)2012,JPO&INPIT |
