| 摘要 |
A sensor unit comprises a connection area (3) having at least one binding site for the analyte, where the connection area undergoes a spatial change when the analyte binds to the binding site; a first fluorescently active region (1); and a second fluorescently active region (9), where the active regions are bound to the connection area in a manner such that, when a spatial change occurs to the connection area due to the analyte binding to the connection area, the distance between the active regions changes without the bonds of the active regions to the connection area being broken. A sensor unit that is functionally stable in an implant, for performing a qualitative and quantitative in vivo determination of an analyte (7), comprises a connection area (3) having at least one binding site for the analyte, where the connection area undergoes a spatial change when the analyte binds to the binding site; a first fluorescently active region (1); and a second fluorescently active region (9), where the first and second fluorescently active regions are bound to the connection area in a manner such that, when a spatial change occurs to the connection area due to the analyte binding to the connection area, the distance between the first and second fluorescently active region changes without the bonds of the fluorescently active regions to the connection area being broken, and where the fluorescently active regions are comprised of an anorganic material (>= 60 wt.%). Independent claims are included for the following: (1) an implant comprising the sensor unit; and (2) performing the qualitative or quantitative in vivo determination of an analyte, involving a) bringing the sensor unit or implant in contact, in or on the body, with a bodily fluid of a human or an animal that at least potentially contains the analyte; b) registering the fluoroscence signal generated by the sensor unit; and c) comparing the generated fluoroscence signal to a reference value or an array of reference values to qualitatively or quantitatively determine the analyte. |
