发明名称 |
Binding domain-immunoglobulin fusion proteins |
摘要 |
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.
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申请公布号 |
US8188237(B2) |
申请公布日期 |
2012.05.29 |
申请号 |
US20100901295 |
申请日期 |
2010.10.08 |
申请人 |
LEDBETTER JEFFREY A.;HAYDEN-LEDBETTER MARTHA SUSAN;EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC |
发明人 |
LEDBETTER JEFFREY A.;HAYDEN-LEDBETTER MARTHA SUSAN |
分类号 |
C07K16/00;C07K16/28;C07K16/46 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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