发明名称 |
INFLUENZA VACCINE WITH IMPROVED PRESEVATION AND STABILITY PROPERTIES COMPRISING A HYDROPHOBIC AMINO ACID, ARGININE AND AN ACID ADDITION SALT |
摘要 |
<p>Disclosed is a lyophilized preparation improved in the stability of an influenza vaccine contained therein. A lyophilized preparation remarkably improved in the stability of an influenza vaccine contained therein can be prepared by lyophilizing an aqueous solution satisfying the following requirements (A) to (C): (A) the aqueous solution contains (i) an influenza vaccine, (ii) a hydrophobic amino acid, and (iii) arginine and an acid addition salt thereof; (B) the component (iii) is contained in an amount of 20 to 85% by weight relative to the total amount of the lyophilized preparation; and (C) the pH value of the aqueous solution aqueous solution is adjusted to pH 8 to 10 by controlling the ratio between arginine and the acid addition salt thereof which constitute the component (iii).</p> |
申请公布号 |
NZ579395(A) |
申请公布日期 |
2012.05.25 |
申请号 |
NZ20080579395 |
申请日期 |
2008.03.07 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
YAMASHITA, CHIKAMASA |
分类号 |
A61K39/145;A61K9/19;A61K47/18;A61P31/16 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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