| 摘要 |
A compound of formula (I) wherein X is O or S; R is H, OH, SH, nitro, NH, NHCalkyl, N(Calkyl), halo, haloCalkyl, CN, C-alkyl, OCalkyl, CalkylCOOH, CalkylCOOCalkyl, C-alkenyl, Ccycloalkyl, Caryl, CalkylCaryl, heterocyclyl, heteroaryl, CONH, CONHCalkyl, CON(Calkyl), OCOCalkyl, or is an acidic group, such as a group comprising a carboxyl, phosphate, phosphinate, sulfate, sulfonate, or tetrazolyl group; R is as defined for R or R and R taken together can form a 6-membered aromatic ring optionally substituted by up to 4 groups R; R is H, halo (preferably fluoro), or CHaI (preferably CF); each R is defined as for R; V is a covalent bond or a Calkyl group, or C-mono or multiply unsaturated alkenyl group; said alkyl or alkenyl groups being optionally interupted by one or more heteroatoms selected from O, NH, N(Calkyl), S, SO, or SO; M is absent or is a C cyclic group or a C aromatic group; and R is H, halo, OH, CN, nitro, NH, NHCalkyl, N(Calkyl), haloCalkyl, a Calkyl group, or C-mono or multiply unsaturated alkenyl group, said Calkyl or Calkenyl groups being optionally interupted by one or more heteroatoms selected from O, NH, N(C1-6 alkyl), S, SO, or SO; with the proviso that the group VMR as a whole provides at least 4 backbone atoms from the C(R) group; or a salt, ester, solvate, N-oxide, or prodrug thereof; for use in the treatment of a chronic inflammatory condition. |
