Cysteine protease inhibitors

摘要

Compounds of the formula I wherein R is H; and R is C-C alkyl, Carbocyclyl or Het; or R and R together define a saturated cyclic amine with 3-6 ring atoms; R and R are H, halo, C-Calkyl, C-Chaloalkyl, C-Calkoxy; or R and R together with the carbon atom to which they are attached form a C-Ccycloalkyl; R is a branched C-Calkyl chain, C-Chaloalkyl or C-Ccycloalkylmethyl, R is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain