发明名称 |
METHODS FOR TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION. |
摘要 |
<p>In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular coagulation. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.</p> |
申请公布号 |
MX2012004343(A) |
申请公布日期 |
2012.05.22 |
申请号 |
MX20120004343 |
申请日期 |
2010.10.15 |
申请人 |
OMEROS CORPORATION |
发明人 |
DEMOPULOS, GREGORY, A.;SCHWAEBLE, HANS-WILHELM;TEDFORD, CLARK, E.;PARENT, JAMES, B.;DUDLER, THOMAS, A. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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