发明名称 Novel Nitroreductase Enzymatic Substrates
摘要 The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; X is NR, CZ5Z6, S or O, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonie, Z5 and Z6 being an alkyl; Y is N or N+R, R being alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; Z1, Z2, Z3 and Z4 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
申请公布号 US2012122137(A1) 申请公布日期 2012.05.17
申请号 US201013387295 申请日期 2010.07.29
申请人 FABREGA OLIVIER;JAMES ARTHUR;ORENGA SYLVAIN;PERRY JOHN;SALWATURA VINDHYA;STANFORTH STEPHEN;BIOMERIEUX S.A. 发明人 FABREGA OLIVIER;JAMES ARTHUR;ORENGA SYLVAIN;PERRY JOHN;SALWATURA VINDHYA;STANFORTH STEPHEN
分类号 C12Q1/26;C07D209/12;C07D209/20;C07D235/06;C07D263/56;C07D277/64 主分类号 C12Q1/26
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