发明名称 |
FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS |
摘要 |
The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity. |
申请公布号 |
US2012108557(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
US201213349688 |
申请日期 |
2012.01.13 |
申请人 |
OWEN GEOFFREY ROBERT;BROOKS AMY C.;BERNAL-PEREZ LINA F.;STROMAN DAVID W.;DAJCS JOSEPH J.;ALCON RESEARCH, LTD. |
发明人 |
OWEN GEOFFREY ROBERT;BROOKS AMY C.;BERNAL-PEREZ LINA F.;STROMAN DAVID W.;DAJCS JOSEPH J. |
分类号 |
A61K31/4709;A61K31/573;A61P27/02;A61P31/00 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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