| 发明名称 |
Modified lecithin-cholesterol acyltransferase enzymes |
| 摘要 |
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide. |
| 申请公布号 |
US8168416(B2) |
申请公布日期 |
2012.05.01 |
| 申请号 |
US20080179815 |
申请日期 |
2008.07.25 |
| 申请人 |
BOONE TOM;MEININGER DAVID PARK;SCHWARZ MARGRIT;SHAN BEI;SHEN WENYAN;ZHOU MINGYUE;AMGEN INC. |
发明人 |
BOONE TOM;MEININGER DAVID PARK;SCHWARZ MARGRIT;SHAN BEI;SHEN WENYAN;ZHOU MINGYUE |
| 分类号 |
C12N9/10;A61K38/45;A61P9/00;C12P21/02 |
主分类号 |
C12N9/10 |
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