DERIVATIVES OF 1-OXO-1,2-DIHYDROISOQUINOLINE-5-CARBOXAMIDES AND OF 4-OXO-3,4-DIHYDROQUINAZOLINE-8-CARBOXAMIDES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS

摘要

Disclosed are derivatives of 1-oxo-1,2-dihydro?isoquinoline-5-carboxamides and of 4-oxo-3,4-dihydroquinazoline-8-carboxamides, of general formula (I), wherein the substituents are disclosed in the specification. Also disclosed is the method of producing said derivatives and the application thereof in therapeutics as â-secretase for treating neurodegenerative disorders such as Alzheimer's disease.