| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to field of medicine. Claimed are immunologically active fragments of polypeptide coded by nucleic acid TOM 34, which possess ability to induce cytotoxic T-cells, containing amino acid sequence SEQ ID NO:7, in which second amino acid from N-end is substituted and represents phenylalanine, tyrosine, methionine or tryptophan, and/or where 1 or 2 amino acids are added on N-end and/or C-end, and/or where C-end amino acid is substituted and represents phenylalanine, leucine, isoleucine, tryptophan or methionine. ^ EFFECT: invention provides novel epitope for efficient immunotherapy of large intestine cancer. ^ 3 cl, 10 dwg, 3 tbl |
