发明名称 |
PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF |
摘要 |
The present invention provides pyrazole derivatives represented by the general formula: (see formula I) wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: (see formula II) or a group represented by the general formula: (see formula III) while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc. ; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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申请公布号 |
CA2494179(C) |
申请公布日期 |
2012.04.24 |
申请号 |
CA20032494179 |
申请日期 |
2003.08.07 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
TERANISHI, HIROTAKA;FUSHIMI, NOBUHIKO;YONEKUBO, SHIGERU;SHIMIZU, KAZUO;SHIBAZAKI, TOSHIHIDE;ISAJI, MASAYUKI |
分类号 |
C07H17/02;A61K31/7056;A61P3/04;A61P3/06;A61P3/10;A61P9/04;A61P9/10;A61P9/12;A61P19/06;A61P43/00;C07D405/12 |
主分类号 |
C07H17/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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