发明名称 |
Dual chain synthetic heparin-binding growth factor analogs |
摘要 |
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices. |
申请公布号 |
US8163717(B2) |
申请公布日期 |
2012.04.24 |
申请号 |
US20090574484 |
申请日期 |
2009.10.06 |
申请人 |
ZAMORA PAUL O.;PENA LOUIS A.;LIN XINHUA;BIOSURFACE ENGINEERING TECHNOLOGIES, INC. |
发明人 |
ZAMORA PAUL O.;PENA LOUIS A.;LIN XINHUA |
分类号 |
A61K38/00;A61K31/727;A61K38/18;A61K38/24;A61L27/34;C07K14/00;C07K14/475;C07K14/50;C07K16/00;C08H1/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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