发明名称 |
METHODS FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES |
摘要 |
The inventors demonstrate that treatment of young, suckling mice with a glycolipid derived from Helicobacter pylori activates NKT cells in a CD1d-restricted fashion, and is protective against AHR in a model of allergen-induced asthma. The inventors further found that this protective effect can be transferred by NKT cells exposed to the glycolipid, and is associated with the expansion of a suppressive double-negative NKT cells and Foxp3+ TReg cells. The inventors also demonstrate herein that pre-treatment of adult mice with a glycolipid derived from Helicobacter pylori partially suppresses airway hyperreactivity and inhibits BAL inflammation in an ozone-exposure model. Accordingly, provided herein are compositions and methods for the treatment and prevention of inflammatory diseases, such as asthma or autoimmune diseases, in a subject in need thereof. |
申请公布号 |
WO2011149881(A3) |
申请公布日期 |
2012.04.19 |
申请号 |
WO2011US37664 |
申请日期 |
2011.05.24 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;UNIVERSITY OF BIRMINGHAM;UMETSU, DALE T.;DEKRUYFF, ROSEMARIE H.;CHANG, YA-JEN;ILLARIONOV, PETR |
发明人 |
UMETSU, DALE T.;DEKRUYFF, ROSEMARIE H.;CHANG, YA-JEN;ILLARIONOV, PETR |
分类号 |
A61K31/704;A61K31/56;A61K31/70;A61P11/00;A61P29/00 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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