发明名称 |
CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF |
摘要 |
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group while the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compound; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics. |
申请公布号 |
US2012095040(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201013319908 |
申请日期 |
2010.05.11 |
申请人 |
ABOUABDELLAH AHMED;EVEN LUC;FAYOL AUDE;VACHE JULIEN;YAUCHE PHILIPPE;SANOFI |
发明人 |
ABOUABDELLAH AHMED;EVEN LUC;FAYOL AUDE;VACHE JULIEN;YAUCHE PHILIPPE |
分类号 |
A61K31/4725;A61K31/4196;A61K31/422;A61K31/427;A61K31/428;A61K31/433;A61P1/00;A61P1/08;A61P9/00;A61P9/10;A61P11/00;A61P13/00;A61P13/10;A61P19/10;A61P25/00;A61P25/08;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P37/00;A61P37/08;C07D403/12;C07D413/12;C07D413/14;C07D417/12;C07D417/14 |
主分类号 |
A61K31/4725 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|