发明名称 |
Peptide inhibitors of ABL kinases |
摘要 |
Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provided are methods of determining whether an agent is a candidate inhibitor of an AbI kinase. Further provided are methods of inhibiting an AbI kinase. Also provided are methods of treating a patient having a condition characterized by a mutant AbI kinase. Additionally provided are methods of treating a patient at risk for a condition characterized by a mutant AbI kinase. Methods of labeling an AbI kinase are also provided. Additionally, methods of isolating an AbI kinase from a tissue are provided. |
申请公布号 |
US8148320(B2) |
申请公布日期 |
2012.04.03 |
申请号 |
US20060095728 |
申请日期 |
2006.11.29 |
申请人 |
KOTULA LESZEK;XIONG XIAOLING;NEW YORK BLOOD CENTER, INC. |
发明人 |
KOTULA LESZEK;XIONG XIAOLING |
分类号 |
A61K38/16;A61K38/10;A61P35/00;C07K7/08;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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