发明名称 |
Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies |
摘要 |
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent. |
申请公布号 |
US8147798(B2) |
申请公布日期 |
2012.04.03 |
申请号 |
US20050666083 |
申请日期 |
2005.07.01 |
申请人 |
KLUNK WILLIAM E.;MATHIS, JR. CHESTER A.;UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
KLUNK WILLIAM E.;MATHIS, JR. CHESTER A. |
分类号 |
A61K49/00;A61K51/00 |
主分类号 |
A61K49/00 |
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