ACID ADDITION SALTS, HYDRATES AND POLYMORPHS OF 5-(2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE AND FORMULATIONS COMPRISING THESE FORMS

摘要

Disclosed herein is 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morphonlin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide mesylate, in particular the crystalline form which has an X-ray diffraction pattern with peaks of about 8.0, 11.9, 13.9, 14.2, 16+.7, 18.5, 19.4, 22.7, 23.3 +/- 0.2 degrees 2è is preferred. Also disclosed are the hydrate forms HA and HB, preparation of said compounds in each form and an aqueous formulation comprising is 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morphonlin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide mesylate being free from any other salts having a pH between 3.2 and 5.2.