A SPRAY DRIED POWDER FORMULATION FOR VACCINES ENTRAPPING ALUM AND THE ANTIGEN IN BIODEGRADABLE POLYMER PARTICLES

摘要

The present invention relates to a novel effective dry powder vaccine formulation that increases the immune response in the host. The formulation comprises of an antigen entrapped into a polymer particle, coated with alum, finally spray dried into a dry powder. This formulation is used to elicit long lasting higher antibody titers than alum adsorbed antigen or admixture of polymer entrapped antigen and alum.