| 发明名称 |
INHIBITORS OF SERINE PROTEASE, PARTICULARLY HEPATITIS C VIRUS NS3-NS4A PROTEASE, INCORPORATING A FUSED RING SYSTEM |
| 摘要 |
The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. |
| 申请公布号 |
EP1441720(B8) |
申请公布日期 |
2012.03.28 |
| 申请号 |
EP20020782236 |
申请日期 |
2002.10.24 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
PERNI, ROBERT, B.;PITLIK, JANOS;VAN DRIE, JOHN, H.;FARMER, LUC, J. |
| 分类号 |
A61K31/403;C12N9/99;A61K31/13;A61K31/497;A61K31/7052;A61K38/00;A61K38/21;A61K45/00;A61P31/12;A61P31/14;A61P43/00;C07D403/12;C07K5/023;C07K5/06;C07K5/08;C07K5/083;C07K5/10;C07K5/103;C07K7/02;C07K7/06 |
主分类号 |
A61K31/403 |
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