A BROADLY PROTECTIVE PROTEIN OF BRUCELLA AND ITS USE IN BRUCELLOSIS VACCINE PREPARATION

摘要

A vaccine has a Brucella adhesin (BrAd) polypeptide. The vaccine is capable of conferring immunity against a plurality of Brucella species, including but not limited to B. abortus, B. melitensis and B. suis. Additionally, an isolated nucleic acid sequence encoding a Brucella adhesin polypeptide is disclosed. The nucleic acid sequence may be inserted into a plasmid and introduced into a Brucella strain to confer immunity against a plurality of pathogenic Brucella species. Further, a method of treating or preventing brucellosis comprising administering a vaccine having a Brucella adhesin (BrAd) polypeptide.