| 发明名称 |
Method for producing phosphorus-containing compounds |
| 摘要 |
<p>The invention concerns a method for producing a compound of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="57" wi="141" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
by reacting rapamycin with (R)(R)P(=O)-Cl or (R)(RO)P(=O)-Cl to form the compound,
wherein each occurrence of R is aryl or is an independently chosen C<Sub>1</Sub>-C<Sub>6</Sub> alkyl group optionally bearing one or more halo, -OH, alkoxyl-, alkyloxyLalkyloxyl-, haloalkyl-, hydroxyalkoxyl-, acyl-, acyloxy-, heterocyclic, aryl or heteroaryl substituents.</p> |
| 申请公布号 |
EP2407473(A3) |
申请公布日期 |
2012.03.21 |
| 申请号 |
EP20110180546 |
申请日期 |
2003.02.03 |
| 申请人 |
ARIAD PHARMACEUTICALS, INC |
发明人 |
BERSTEIN, DAVID, L.;METCALF, CHESTER A., III;ROZAMUS, LEONARD W.;WANG, YIHAN |
| 分类号 |
A61L27/00;C07F9/6561;A61F2/84;A61K31/661;A61K31/662;A61K31/664;A61K45/00;A61K45/06;A61P1/04;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P17/02;A61P17/04;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P31/10;A61P35/00;A61P35/02;A61P37/00;C07D498/18;C07F9/09;C07F9/22;C07F9/32;C07F9/36;C07F9/40;C07F9/44;C07F9/46;C07F9/53 |
主分类号 |
A61L27/00 |
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