发明名称 |
SULPHONATE PRECURSOR HAVING A 1,2,3-TRIAZOLIUM SALT, A PRODUCTION METHOD THEREFOR AND AN INTRAMOLECULAR NUCLEOPHILIC FLUORINATION REACTION USING THE SAME |
摘要 |
The present invention relates to a sulphonate precursor having a 1,2,3-triazolium salt, and to a production method and use therefor, and more specifically exhibits the advantages that the reaction rate can be increased by introducing an organic salt having a phase-transfer catalyst effect into the leaving group of the precursor and thereby inducing an intramolecular nucleophilic substitution reaction of the nucleophile and sulphonate precursor, and use of a separate phase-transfer catalyst is avoided. The invention can be used as a sulphonate precursor for the effective production of an [18F]radiopharmaceutical used in positron emission tomography. |
申请公布号 |
WO2012033374(A2) |
申请公布日期 |
2012.03.15 |
申请号 |
WO2011KR06682 |
申请日期 |
2011.09.08 |
申请人 |
INDUSTRY-UNIVERSITY COOPERATION FOUNDATION SOGANGUNIVERSITY;CHI, DAE-YOON;LEE, BYOUNG-SE;CHU, SO-YOUNG;LEE, JAE-HAK;KWON, HYE-RIM |
发明人 |
CHI, DAE-YOON;LEE, BYOUNG-SE;CHU, SO-YOUNG;LEE, JAE-HAK;KWON, HYE-RIM |
分类号 |
C07D249/04;C07D405/12;C07D405/14 |
主分类号 |
C07D249/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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