USE OF A LINEAR DNA EXPRESSION CONSTRUCT WITH COVALENTLY CLOSED ENDS
摘要
The present invention relates to a linear DNA expression construct having covalently closed ends, comprising an expression cassette comprising a coding sequence encoding for a gene therapy anti-cancer agent for use in the treatment of cancer, wherein said DNA expression construct is suitable for administration into cells or tissues by a physical transfection method. Preferably, said DNA expression construct consists of a dumbbell-shaped circular strand of DNA.
申请公布号
WO2012032126(A1)
申请公布日期
2012.03.15
申请号
WO2011EP65569
申请日期
2011.09.08
申请人
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN BERLIN-BUCH;WALTHER, WOLFGANG;KOBELT, DENNIS;SCHLAG, PETER, M.;SCHMIDT, MANUEL
发明人
WALTHER, WOLFGANG;KOBELT, DENNIS;SCHLAG, PETER, M.;SCHMIDT, MANUEL