发明名称 |
PROCESS TO FORM AN ORALLY DISINTEGRATING TABLET FOR HUMAN USE |
摘要 |
The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet. |
申请公布号 |
EP2424496(A1) |
申请公布日期 |
2012.03.07 |
申请号 |
EP20100716339 |
申请日期 |
2010.04.28 |
申请人 |
INTERVET INTERNATIONAL B.V.;N.V. ORGANON |
发明人 |
MIDDELBEEK, HANS, ALMER;SMIT, JOZEFUS, A. C.;VERHEEZEN, JACOBUS, JOHANNES, ADRIANA, MARIA |
分类号 |
A61K9/00;A61J1/03;A61K9/20 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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