发明名称 |
Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
摘要 |
Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å. |
申请公布号 |
US8129146(B2) |
申请公布日期 |
2012.03.06 |
申请号 |
US20080104809 |
申请日期 |
2008.04.17 |
申请人 |
KJELDSEN THOMAS BORGLUM;LUDVIGSEN SVEND;NOVO NORDISK A/S |
发明人 |
KJELDSEN THOMAS BORGLUM;LUDVIGSEN SVEND |
分类号 |
C12N15/17;C07K14/62;C12N1/15;C12N1/21 |
主分类号 |
C12N15/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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