发明名称 |
NOVEL PYRAZOLO[1,5-a]PYRROLO[3,2-e]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
摘要 |
<p>The present invention relates to certain pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine compounds.</p> |
申请公布号 |
WO2012027239(A1) |
申请公布日期 |
2012.03.01 |
申请号 |
WO2011US48548 |
申请日期 |
2011.08.22 |
申请人 |
SCHERING CORPORATION;ZHAO, LIANYUN;LIU, DUAN;SIDDIQUI, M. ARSHAD |
发明人 |
ZHAO, LIANYUN;LIU, DUAN;SIDDIQUI, M. ARSHAD |
分类号 |
A01N43/42;A61K31/44 |
主分类号 |
A01N43/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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