发明名称 |
Vault compositions for immunization against chlamydia genital infection |
摘要 |
Methods and compositions are provided herein for immunizing a subject against Chlamydial genital infection by administering to the subject an effective amount of a Chlamydial immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. In some aspects, the vault-like-particles are administered to the nasal mucosa. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity at mucosal surfaces while reducing inflammation associated with Chlamydia infection.
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申请公布号 |
US8124109(B2) |
申请公布日期 |
2012.02.28 |
申请号 |
US20090467255 |
申请日期 |
2009.05.15 |
申请人 |
KICKHOEFER VALERIE A.;ROME LEONARD H.;KELLY KATHLEEN A.;CHAMPION CHERYL I.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
KICKHOEFER VALERIE A.;ROME LEONARD H.;KELLY KATHLEEN A.;CHAMPION CHERYL I. |
分类号 |
A61K39/118 |
主分类号 |
A61K39/118 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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