| 发明名称 |
FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE |
| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to novel fluorinated derivatives of 1,4-naphthoquinone of general formula (II), having cytotoxic effect on human cancer cells in a culture. In formula (II) R = NHCH2COOH, NHCH2COOC2H5, NH(CH2)5COOH, NH(CH2)3COOH, NH(CH2)2COOH, OOC(CH2)3NH2. ^ EFFECT: disclosed compounds can be used in medicine for therapy of malignant growths. ^ 1 dwg, 4 tbl, 5 ex |
| 申请公布号 |
RU2443678(C1) |
申请公布日期 |
2012.02.27 |
| 申请号 |
RU20100142521 |
申请日期 |
2010.10.18 |
| 申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT KHIMICHESKOJ BIOLOGII I FUNDAMENTAL'NOJ MEDITSINY SIBIRSKOGO OTDELENIJA RAN (IKHBFM SO RAN);NOVOSIBIRSKIJ INSTITUT ORGANICHESKOJ KHIMII IM. N.N. VOROZHTSOVA SIBIRSKOGO OTDELENIJA ROSSIJSKOJ AKADEMII NAUK (NIOKH SO RAN) |
发明人 |
NEVINSKIJ GEORGIJ ALEKSANDROVICH;ZAKHAROVA OL'GA DMITRIEVNA;GORJUNOV LEONID IVANOVICH;TROSHKOVA NADEZHDA MIKHAJLOVNA;SHTEJNGARTS VITALIJ DAVIDOVICH |
| 分类号 |
A61P35/00;C07C229/14;C07C229/18 |
主分类号 |
A61P35/00 |
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