A method for determining an analyte in a sample suspected of containing the analyte comprises providing in combination a medium, the sample, and two or more different receptors. Each different receptor binds to at least two different epitopic sites. One of the epitopic sites is a common binding site and one of the epitopic sites is non-common binding site. The non-common epitopic sites are different for each different receptor. The receptors exhibit mono-molecular binding. The medium is incubated under conditions for binding of the receptors to the epitopic sites. The medium is examined for the presence and/or amount of complexes comprising the epitopic sites and the receptors. The presence and/or amount of the complexes indicate the presence and/or amount of the analyte in the sample.
申请公布号
WO2012024416(A1)
申请公布日期
2012.02.23
申请号
WO2011US48107
申请日期
2011.08.17
申请人
SIEMENS HEALTHCARE DIAGNOSTICS INC.;LEWISCH, SANDRA, A.;SCHIAVONI, LYNN, M.;BEDZYK, WILLIAM, D.
发明人
LEWISCH, SANDRA, A.;SCHIAVONI, LYNN, M.;BEDZYK, WILLIAM, D.