| 摘要 |
PURPOSE: A manufacturing method of alkylamine derivatives is provided to optimally reduce the generation of norcarnitine by using the acid of the hydrolysis of dialkylamino ester hydrochloride. CONSTITUTION: A manufacturing method of alkylamine derivatives comprises a step of manufacturing 4-dialkylamino crotonic acid by hydrolyze C1-4 alkyl 4-dialkylamino crotonic acid ester hydrochloride under the presence of acid. The C1-4 alkyl 4-dialkylamino crotonic acid ester hydrochloride is ethyl 4-dimethylamino crotonic acid ester hydrochloride. The acid is hydrochloric acid, sulfuric acid, benzene sulfonic acid, benzene sulfonic acid substituted by a methyl group, carboxylic acid, C1-3 alkyl carboxylic acid, phenyl carboxylic acid, phosphoric acid, bromic acid, or iodic acid.
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