发明名称 |
FIBRIN BASED SCAFFOLD, PREPARATION AND USE THEREOF |
摘要 |
The invention relates to a fibrin-based scaffold suitable for supporting a population of cells comprising mesenchymal stem cells (MSC) and/or umbilical tissue derived cells (UTC) at the site of administration for a prolonged period of time. The scaffold is capable of supporting at least 1×106 cells/ml scaffold. The invention also relates to the preparation of the scaffold and to its use. Preparation of the scaffold is carried out with a fibrinogen component comprising fibrinogen having a final concentration of higher than 17.5 mg/ml scaffold. The scaffold and the embedded MSC and/or UTC can be used for increasing vascularization and/or wound healing at the site of administration.
|
申请公布号 |
US2012039855(A1) |
申请公布日期 |
2012.02.16 |
申请号 |
US201113206715 |
申请日期 |
2011.08.10 |
申请人 |
ATLAS ROEE;NUR ISRAEL;MEIDLER ROBERTO;BAR LILIANA;BUENSUCESO CHARITO;KIHM ANTHONY J.;DHANARAJ SRIDEVI |
发明人 |
ATLAS ROEE;NUR ISRAEL;MEIDLER ROBERTO;BAR LILIANA;BUENSUCESO CHARITO;KIHM ANTHONY J.;DHANARAJ SRIDEVI |
分类号 |
A61K35/12;A61K35/44;A61P9/00;A61P9/10;A61P17/02;B65D71/00;C12P21/00 |
主分类号 |
A61K35/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|