| 摘要 |
FIELD: medicine, pharmacy. ^ SUBSTANCE: invention refers to the field of medicine and pharmacy and refers to the method of production of tableted pharmaceutical form of clozapine (8-Chlorine-11 -(4-methylpiperasine-1-yl)-5H-dibenso [b, e][1, 4] diazepine). The essence of method is pre-produced dry mixture of lactose, potato starch and clozapine is hydrated by 10% water solution of Collidon 25, wet granulation is performed, and then drying is performed at temperature 45-50C. Resulting granules are subject to dry granulation until the productions of granules with average diameter 1.0-1.5 mm, powdered with aerosil and stearic acid and/or its salt. The resulting mixture is pelletized and the tablets are produced with the following mixture ratio,%: ^ Clozapine 23-42 Lactose 47-52 Potato starch 10-20 Collidon 25 4-5 Aerosil 1-2 Stearic acid 1-2 ^ EFFECT: production of clozapine pharmaceutical composition in form of tablets. ^ 2 cl, 5 ex |
