发明名称 |
DIAGNOSTIC METHOD USING PALB2 |
摘要 |
The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.
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申请公布号 |
US2012034318(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
US201013254610 |
申请日期 |
2010.03.05 |
申请人 |
VOGELSTEIN BERT;KINZLER KENNETH W.;PARSONS D. WILLIAMS;JONES SIAN;KERN SCOTT;HRUBAN RALPH;ESHLEMAN JAMES R.;GOGGINS MICHAEL;KLEIN ALISON;HIDALGO MANUEL;VELCULESCU VICTOR E.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
VOGELSTEIN BERT;KINZLER KENNETH W.;PARSONS D. WILLIAMS;JONES SIAN;KERN SCOTT;HRUBAN RALPH;ESHLEMAN JAMES R.;GOGGINS MICHAEL;KLEIN ALISON;HIDALGO MANUEL;VELCULESCU VICTOR E. |
分类号 |
A61K33/24;A61P35/00;C12Q1/68;C40B20/08;G01N33/566;G01N33/577 |
主分类号 |
A61K33/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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