发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
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申请公布号 |
US2012022141(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
US201113252414 |
申请日期 |
2011.10.04 |
申请人 |
TAN PAMELA;SAH DINAH;BRAMLAGE BIRGIT |
发明人 |
TAN PAMELA;SAH DINAH;BRAMLAGE BIRGIT |
分类号 |
A61K31/713;A61P31/20;C07H21/02;C12N5/071;C12N5/10;C12N15/113;C12N15/63 |
主分类号 |
A61K31/713 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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