An optical microscope (101) with heightened resolution and capable of providing three dimensional images is disclosed and described. The microscope (101) can include a sample stage (160) for mounting a sample having a plurality of probe molecules. At least one non-coherent light source (127) can be provided. At least one lens (140a, 140b) can be configured to direct a beam of light from the at least one non-coherent light source (127) toward the sample causing the probe molecules to luminesce. A camera (155) can be configured to detect luminescence from the probe molecules. A light beam path modification module (132, 150) can be configured to alter a path length of the probe molecule luminescence to allow camera luminescence detection at a plurality of object planes.
申请公布号
EP2409139(A2)
申请公布日期
2012.01.25
申请号
EP20100754137
申请日期
2010.03.18
申请人
UNIVERSITY OF UTAH RESEARCH FOUNDATION;THE JACKSON LABORATORY;UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES