发明名称 |
AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES |
摘要 |
<p>The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sm14 protein (BCG Pasteur ”leuD/p”K410-hsp60*-Sm14). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct p”K410-hsp60*-Sm14. The efficacy of the BCG Pasteur ”leuD/p”K410-hsp60*-Sm14 strain in the control of the Schistossoma mansoni infection based on the recombinant Sm14 antigen in vivo is showed in the present invention.</p> |
申请公布号 |
EP2407545(A1) |
申请公布日期 |
2012.01.18 |
申请号 |
EP20100750256 |
申请日期 |
2010.03.10 |
申请人 |
FUNDACAO OSWALDO CRUZ |
发明人 |
TENDLER, MIRIAM;VILAR, MONICA MAGNO;ARMOA, GERALDO RODRIGUES GARCIA;MCINTOSH, DOUGLAS;SIMPSON, ANDREW, J., G. |
分类号 |
C12N15/76;A61P31/06;A61P33/10;A61P35/00 |
主分类号 |
C12N15/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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