发明名称 |
RENAL CELL CARCINOMA BIOMARKERS |
摘要 |
Disclosed herein is a method of identifying a tumor biomarker. In one example, a tumor biomarker is identified by obtaining a peripheral biological fluid sample from a subject with a tumor as well as a tumor sample and an adjacent non-tumor sample from such subject. A protein expression profile is detected in the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample. The protein expression profiles of the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample are then compared, wherein an increase in expression of a specific protein in the tumor sample and peripheral biological fluid sample but not in the adjacent non-tumor sample indicates that the specific protein is a biomarker of the tumor. Also disclosed herein is a gene profiling signature that can be used to diagnosis a subject with renal cell carcinoma (RCC) or to identify agents with therapeutic potential to treat RCC. Thus, methods of diagnosing a subject with RCC are disclosed. Methods are also provided for identifying agents that alter an activity of a RCC biomarker. |
申请公布号 |
US2012009201(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
US200913257580 |
申请日期 |
2009.03.20 |
申请人 |
BLONDER JOSIP;WEI BIH-RONG;JOHANN DONALD J.;VEENSTRA TIMOTHY D. |
发明人 |
BLONDER JOSIP;WEI BIH-RONG;JOHANN DONALD J.;VEENSTRA TIMOTHY D. |
分类号 |
A61K39/395;A61K31/713;A61P35/00;C07H21/00;C07K16/18;C07K16/40;C12Q1/37;C12Q1/68;C40B30/04;G01N33/53;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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