| 摘要 |
The invention relates to medicine, in particular to oncourinology, and concerns a method of differential diagnostics of prostate cancer and benign prostatic hyperplasia. According to the invention the patient age and total prostate-specific antigen (PSA) level in blood serum are determined, digital rectal investigation is made, prostate gland sonography with measurement of its volume and biopsy with pathohistological examination is carried out. Tumors are differentiated by Gleason scoring system, and the diagnostic model is verified by ROC-analysis. In addition free:total PSA ratio and prostate-specific antigen density is determined, and probabilityof reliability of benign prostatic hyperplasia prediction in patients with suspicion of prostate cancer is detected by means of binary regression logistic equation. Whenis greater than 0.5, benign prostatic hyperplasia is supposed, and whenless than 0.5, prostate cancer is predicted with such indices of diagnostic test quality as overall sensitivity of 89.5%, specificity of 81.4% and high predictive value according to ROC-curve bounds: area under curve R2=0.94 and significance p=0.0001. |
