Production of polyunsaturated fatty acids in oleaginous yeasts

摘要

The present invention relates to methods for the production of omega-3 and/or omega-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to gamma-linolenic acid (GLA); alpha-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-gamma- linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to arachidonic acid (ARA); ETA to eicosapentaenoic acid (EPA); DGLA to ETA; EPA to docosapentaenoic acid (DPA); and ARA to EPA have been introduced into the genome of Yarrowia for synthesis of ARA and EPA.