发明名称 |
Process for obtaining high efficiency human albumin for use in detoxification therapy |
摘要 |
A process for purifying and collecting albumin from plasma and plasma fractions involves diafiltration of an albumin-containing plasma fraction; stabilizing the resulting albumin fraction with sodium chloride and an amino acid in the absence of any added fatty acid; pasteurizing the stabilized albumin fraction; and diafiltering the pasteurized fraction to remove, along other things, stabilizers. In one embodiment, the amino acid stabilizing agent is acetyl tryptophan. The resulting albumin has at least about 80% albumin binding capacity relative to natural plasma albumin, and is storage stable for about 30 months at 30° C. |
申请公布号 |
US8088416(B2) |
申请公布日期 |
2012.01.03 |
申请号 |
US20080268590 |
申请日期 |
2008.11.11 |
申请人 |
JORQUERA NIETO JUAN IGNACIO;RISTOL DEBART PERE;COSTA RIEROLA MONTSERRAT;GRIFOLS, S.A. |
发明人 |
JORQUERA NIETO JUAN IGNACIO;RISTOL DEBART PERE;COSTA RIEROLA MONTSERRAT |
分类号 |
A61K35/14 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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地址 |
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