COMPOSITIONS COMPRISING PRFA*MUTANT LISTERIA AND METHODS OF USE THEREOF
摘要
The invention provides recombinant Listeria that constitutively express Prf A and comprise polynucleotides that encode polypeptides such as tumor or infectious agent antigens, operably linked to a PrfA responsive regulatory agent. Methods of using the Listeria, and compositions thereof, to induce or enhance an immune response and/or in the treatment of disease are provided. Methods of producing the bacteria are also provided.
申请公布号
EP2283112(A4)
申请公布日期
2011.12.28
申请号
EP20090751313
申请日期
2009.05.18
申请人
ADURO BIOTECH
发明人
LAUER, PETER, M.;DUBENSKY, THOMAS, W., JR.;SKOBLE, JUSTIN;BROCKSTEDT, DIRK, G.;LUCKETT, WILLIAM, STANFORD, JR.;HANSON, WILLIAM